COMBINATORIAL CHEMISTRY AND SOLID PHASE SYNTHESIS

COMBINATORIAL CHEMISTRY AND SOLID PHASE SYNTHESIS

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iten
Codice
94833
ANNO ACCADEMICO
2019/2020
CFU
3 cfu al 2° anno di 9017 SCIENZA E INGEGNERIA DEI MATERIALI (LM-53) GENOVA
SETTORE SCIENTIFICO DISCIPLINARE
CHIM/06
LINGUA
Inglese
SEDE
GENOVA (SCIENZA E INGEGNERIA DEI MATERIALI )
periodo
2° Semestre
materiale didattico

PRESENTAZIONE

The course is giving basic information about solid-phase synthesis and its applications

OBIETTIVI E CONTENUTI

OBIETTIVI FORMATIVI

The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science.

Modalità didattiche

Traditional lectures, Computer-room laboratory for bibliographic search through serching engines, elaboration of powerpoint presentations and relevant discussion

PROGRAMMA/CONTENUTO

Introduction to the drug discovery process and to the limitations connected with traditional synthesis.

Use of enabling technologies to speed the purification processes: soluble and insoluble polymers.

Resins for solid-phase synthesis: preparation, characterization, loading, properties. Macroscopic solid supports.

Solid phase synthesis: handles, linkers, loading and cleavage strategies, examples of organic reactions, analytical methods.

Combinatorial chemistry: parallel and mix&split synthesis. Deconvolutive methods and tagging. On-bead and off-bead tests.

Combinatorial chemistry and material science: introduction, general principles, analogy and differences with organic synthesis combichem

Examples taken from the recent literature

The use of search engines

TESTI/BIBLIOGRAFIA

“Solid-phase synthesis and combinatorial technologies” P. Seneci; Wiley Interscience, New York. ISBN 0-471-33195-3

“Solid phase peptide synthesis : a practical approach” E. Atherton, R.C. Sheppard; Oxford University Press. ISBN 0-19-963066-6 

DOCENTI E COMMISSIONI

Ricevimento: su appuntamento

LEZIONI

Modalità didattiche

Traditional lectures, Computer-room laboratory for bibliographic search through serching engines, elaboration of powerpoint presentations and relevant discussion

ESAMI

Modalità d'esame

Oral examination and powerpoint presentation

Modalità di accertamento

The students will be asked to prepare a powerpoint presentation on a specific subject, chosen in agreement with the teacher. The main exam will be an oral examination where general questions on the course matter will be asked