BIOSENSORS AND MICROSYSTEMS

iten
Code
106747
ACADEMIC YEAR
2021/2022
CREDITS
6 credits during the 1st year of 11159 BIOENGINEERING (LM-21) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR
ING-IND/34
TEACHING LOCATION
GENOVA (BIOENGINEERING)
semester
2° Semester
Teaching materials

AIMS AND CONTENT

LEARNING OUTCOMES

La prima parte del corso vuole fornire le nozioni di base sui componenti principali di un biosensore: elemento sensibile e trasduttore, e descrivere gli ambiti di applicazione dei biosensori. In particolare verranno descritte le biomolecole utilizzabili, le strategie di immobilizzazione di tali biomolecole ed i meccanismi di riconoscimento basati su legami di affinità o biocatalisi, i principi di trasduzione chimico-fisica utilizzati, oltre ad alcuni criteri di progettazione in base alle specifiche richieste. La seconda parte del corso mira a fornire le nozioni principali riguardo ai microsistemi applicati alla medicina ed alle biotecnologie, con particolare enfasi sugli effetti della miniaturizzazione e sulle tecniche di microfabbricazione. Verranno anche descritti aspetti specifici dei microsistemi come la microfluidica e l'integrazione tra sensori ed attuatori con esempi di sistemi esistenti e delle opportunità di sviluppo sul mercato.

AIMS AND LEARNING OUTCOMES

Biosensors: 

- to understand working principles of biosensors

- to read and understand the biosensor "jargon"

- to critically view their potential applications and advantages compared to standard analytical techniques

• chemical- and bio-sensor definitions

• most important figures of merit

• biorecognition elements and immobilization procedures

• transducing principles

• main areas of applications

Microsystems:

• to get an overview of

   – the main components of a microsystem

   – the physical phenomena ruling at the microscale

• to learn the most common fabrication technologies for microsystems (to become familiar with the possibilities and limitations of such technologies)

• to get an overview the main biomedical applications of microsytems and products on the market

• to see some future trends and promising technologies

TEACHING METHODS

\Traditional lectures in the classroom, flipped classroom for some topics. T\wo labworks

 

SYLLABUS/CONTENT

• basic concepts of Chemical- and Bio- Sensors

  – physical/chemical/bio sensor definitions/classification

  – molecular bonds

  – proteins (antibodies, enzymes) and nucleic acids

  – sensor characteristics

• molecular sensing elements (bioreceptors)

• immobilization techniques

• immunoassays

• transducers

  – electrochemical

    • amperometric/potentiometric electrodes

    • FET-based

  – optical

  - piezoelectric

Microsystems

• introduction (definitons, some examples, miniaturization)

• scaling laws

• microfluidics

• silicon microfabrication techniques

• alternative microfabrication techniques

• packaging

• microactuators

• microsystems in biotechnology and medicine

RECOMMENDED READING/BIBLIOGRAPHY

Slide and other teaching materials will be provided

TEACHERS AND EXAM BOARD

Office hours: By appointment. Please contact by email: roberto.raiteri@unige.it

Exam Board

ROBERTO RAITERI (President)

SERGIO MARTINOIA

LAURA PASTORINO (President Substitute)

LESSONS

TEACHING METHODS

\Traditional lectures in the classroom, flipped classroom for some topics. T\wo labworks

 

Class schedule

All class schedules are posted on the EasyAcademy portal.

EXAMS

EXAM DESCRIPTION

The ezam will consist in an oral test.

ASSESSMENT METHODS

The aim of the exam will be to evaluate the level of the learning outcomes of the course reached by the student.