GENERAL PHYSIOPATHOLOGY

iten
Code
67362
ACADEMIC YEAR
2021/2022
CREDITS
8 credits during the 3nd year of 8745 MEDICINE AND SURGERY (LM-41) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR
MED/04
LANGUAGE
Italian
TEACHING LOCATION
GENOVA (MEDICINE AND SURGERY)
semester
1° Semester
Prerequisites
Prerequisites
You can take the exam for this unit if you passed the following exam(s):
  • MEDICINE AND SURGERY 8745 (coorte 2019/2020)
  • HUMAN PHYSIOLOGY 2 61193
Prerequisites (for future units)
This unit is a prerequisite for:
  • MEDICINE AND SURGERY 8745 (coorte 2019/2020)
  • DERMATOLOGY, CLINICAL IMMUNOLOGY AND RHEUMATOLOGY 67377
  • CARDIOLOGY AND PNEUMOLOGY 67384
  • PHARMACOLOGY I 67371
  • PHARMACOLOGY 80794
  • GU TRACT AND ENDOCRINE DISEASES 67391
Teaching materials

OVERVIEW

The course gives students the fundamental elements of pathophysiology, which are essential for the successive comprehension of clinical medical sciences.

AIMS AND CONTENT

LEARNING OUTCOMES

Physiopathology is a branch of medicine that combines physiology and pathology especially in the study of altered bodily function in disease. The learning outcome is the knowledge of the main physiopathological mechanisms of organs and systems,  in order to recognize the mechanisms and causes of their malfunction, and to be able to interpret the symptoms, which will be exposed to the students in the successive clinical courses

AIMS AND LEARNING OUTCOMES

Knowledge of the main physiopathological mechanisms of organs and systems, with particular regard to blood, liver, kidney, respiratory and digestive systems, some aspects of endocrinology and metabolism, and the physiopathology of neoplasms.

PREREQUISITES

basic knowledge in anatomy, histology, biochemistry, immunology and physiology

TEACHING METHODS

Lectures, with any possible dialectic interaction with students

In case of sanitary emergency, lessons will switch to remote learning

SYLLABUS/CONTENT

Hematopoiesis, hematopoietic stem cell (HSC), mesenchimal stem cell (MSC), HSC transplant (HSCT).

Erythropoiesis, classification and examples of anemia: aplastic, paroxysmal nocturnal nemoglobinuria (PNH), immune hemolytic, deficiency (Fe, B12 and B9), drugs-mediated, secondary to chronic disorders.

Hemostasis and examples of hemostasis disorders (endothelium, platelets or coagulation factors abnormalities).

Oncology: benign and malign neoplasms, metastasis, local and systemic effects, paraneoplastic syndromes. Epidemiology (risk and prognostic factors). Molecular basis of tumor transformation: oncogenes, oncosuppressors and examples of tumors. Epigenetic mechanisms (methylation, miRNA). Hematological malignances: classification and examples of myeloid and lymphoid neoplasms. Cancer stem cells (CSC), Tumor-associated angiogenesis and tumor microenvironment. Immune responses against cancer, tumor escape mechanisms, tumor-associated inflammation.

Pathogenesis and consequences of dyslipidemias. Atherosclerosis, cardiovascular diseases, Acute rheumatic fever (ARF), essential and secondary hypertension.

Classification of renal diseases, and acute and chronic renal failure. Hydro-electrolytic balance, in particular sodium and potassium. Acid base balance and its alterations.

Pathogenesis and pathophysiology of diabetes mellitus.

Pathophysiology of lipoprotein metabolism

Examples of nitrogen metabolism: phenylketonuria, hyperhomocystinemias, gout

Pathophysiology of the respiratory system.

Pathophysiology of the liver and the biliary tract: acute and chronic hepatitis, cirrhosis and ascites, hepatic failure, portal hypertension, cholestasis, icterus, systemic effects of liver damage

Liver metabolic diseases: Alpha-1 antitrypsin deficiency
Hemochromatosis and Hemosiderosis
Wilson disease
Overview of most common digestive disorders
Overview of most common pancreatic  disorders

RECOMMENDED READING/BIBLIOGRAPHY

Robbins & Cotran Pathologic Basis of Disease, Elsevier

The didactic material is available in pdf format for download (https://www.aulaweb.unige.it). The aim of the course is also to familiarize students with online biomedical scientific literature (https://www.ncbi.nlm.nih.gov/pubmed)

TEACHERS AND EXAM BOARD

Office hours: By appointment Email: Cristina.Bottino@unige.it

Office hours: For appointments, contact the Professor via email at: Nicola.Traverso@unige.it. The teacher's office is located in the General Pathology Section of DIMES, Via Leon Battista Alberti 2, 1st floor, 16132 Genoa Nicola Traverso is the Coordinator of the Integrated Course of Clinical Pathology and Immunohematology  

Office hours: students can send  email to make an appointment; anna.maria.bassi@unige.it  

Office hours: The reception of the students is agreed from time to time, according to the needs and deadlines, by e-mail to the following address: Cinzia.Domenicotti@unige.it The office is located at General Pathology Section - DIMES via LB Alberti 2- Genoa tel +39 010 3538830

Exam Board

CRISTINA BOTTINO (President)

NICOLA TRAVERSO (President)

ANNA MARIA BASSI

CINZIA MARIA DOMENICOTTI

LESSONS

TEACHING METHODS

Lectures, with any possible dialectic interaction with students

In case of sanitary emergency, lessons will switch to remote learning

LESSONS START

1st semester, 3rd year

Class schedule

All class schedules are posted on the EasyAcademy portal.

EXAMS

EXAM DESCRIPTION

The end-of-course exam aims to evaluate the achievement of the educational objectives of the course. The exams take place on the dates indicated in the calendar. Verification is oral, conducted by two teachers for each student. The grade is assigned as a weighted average. The teachers verify the achievement of the educational objectives by asking diversified questions relating to the programs actually carried out during the lesson hours. When the educational objectives have not been achieved, the student is invited to better verify his knowledge and to take the exam again in its entirety. There are no student reception hours, but students can contact the teachers by email in order to make an appointment for further explanations.

Exam Commission

Proff. Cristina Bottino, Nicola traverso, Cinzia Domenicotti, Anna Bassi

ASSESSMENT METHODS

Verification of learning takes place only through the final exam which aims to verify the actual acquisition, by the student, of the expected learning outcomes. In order to pass the exam, with a score of not less than 18/30, the student must demonstrate that they know and connect the topics covered during the course

The following contribute to the final mark expressed out of thirty:

- Ability to deal with the requested topics in a transversal and critical manner;

- Correctness, clarity, synthesis and fluidity of presentation;

- Mastery of the subject;

- Adoption of appropriate terminology

The mark of 30/30 with possible honors will be awarded when the knowledge / skills of the subject are excellent.

Exam schedule

Date Time Location Type Notes
13/12/2021 09:00 GENOVA Orale Pre-appello riservato agli studenti regolarmente iscritti al 3 anno CdL Medicina o iscritti con riserva al IV anno Gli esami si svolgeranno in presenza. Aula Patologia Generale - Edificio 7 (ex patologia generale)
11/01/2022 09:00 GENOVA Orale Vista la gravità della curva epidemiologica e mancando ad oggi precise indicazioni da parte dei CdL, I docenti hanno deciso all'unanimità di svolgere gli esami solo online MEDICINA: Ora: 9 - codice team 2ii6p2r Lettera estratta: D per i canali delle interrogazioni consultare il file che sarà presente nel team Il file con i voti sarà consultabile nel team. Eventuali rifiuti dovranno essere comunicati per mail a Cristina.Bottino@unige.it entro il 12 dicembre ODONTOIATRIA: Ora: 9:30 - codice team jlmg1pu gli studenti sosterranno l'esame prima con la prof. Ricciarelli, in seguito con la prof. Bottino collegandosi sul canale team di medicina (2ii6p2r) Il file con i voti sarà consultabile nel team. Eventuali rifiuti dovranno essere comunicati per mail a Cristina.Bottino@unige.it entro il 12 Dicembre.
01/02/2022 09:00 GENOVA Orale
22/02/2022 09:00 GENOVA Orale
10/05/2022 09:00 GENOVA Orale Appello riservato agli studenti fuoricorso o ripetenti senza obbligo di frequenza
07/06/2022 09:00 GENOVA Orale
28/06/2022 09:00 GENOVA Orale
19/07/2022 09:00 GENOVA Orale
06/09/2022 09:00 GENOVA Orale
20/09/2022 09:00 GENOVA Orale

FURTHER INFORMATION

The didactic material is available in pdf format for download (Teams or Aulaweb)