OVERVIEW

The course is developed with a theoretical (40 hrs) and practical lessons (54 hrs for each student) concerning the pre-treatment and the quantitative determination of substances of pharmaceutical interest, using classical and innovative methods. The topics of the theoretical course are conducted in close correlation with the practical trainings in laboratory. The frontal teaching can be also carried out remotely in telematic mode.

AIMS AND LEARNING OUTCOMES

The course, divided into lectures and individual trainings in laboratory, aims to provide a basic understanding about the methods for the preparation and for the quantitative determination of compounds with medicinal use.

Teaching methods

The course is developed with a theoretical (40 hrs) and practical lessons (54 hrs for each student) concerning the pre-treatment and the quantitative dosage of substances of pharmaceutical interest, using classical and innovative methods. 

SYLLABUS/CONTENT

Theoretical topics

Guidelines on laboratory safety and chemical use

Introduction to the quantitative determination of compounds registered in FU XII Ed. and FE VIII Ed.

Overview of the analytical methods. Classification and selection of analitycal methods. Chemical analysis stages. Chemical, apparatus and methods for the quantitative determination of compounds with medicinal uses. Calculation used in pharmaceutical analysis. Sampling, standardization and calibration.

Introduction to volumetric titrations in pharmaceutical analysis: chemical equilibria in volumetric analysis. Preparation of standard solutions.

Techniques of preparing sample: filtration, extraction, distillation, chromatography

Quantitative determination and applications: neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, potentiometry.

Atomic absorption spectrometry (AAS) and applications.

Practical trainings

Extraction with solvent, distillation in vacuo. Chromatographyc separation and analysis of a mixture of drugs. Quantitative determination of drugs by mean of neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, potentiometry and AAS.

RECOMMENDED READING/BIBLIOGRAPHY

• Fondamenti di chimica analitica di Skoog e West, Terza Edizione - F. James Holler e Stanley R. Crouch, EDISES – ISBN 9788879598651, on line dal 20 marzo 2015.

• Analisi chimico farmaceutica - F. Savelli, O. Bruno - PICCIN

Exam Board

MICHELE TONELLI (President)

PAOLA FOSSA

ELENA CICHERO

CHIARA BRULLO

Teaching methods

The course is developed with a theoretical (40 hrs) and practical lessons (54 hrs for each student) concerning the pre-treatment and the quantitative dosage of substances of pharmaceutical interest, using classical and innovative methods. 

Exam description

Oral test. Exams can be also carried out remotely in telematic mode.

Assessment methods

The examination includes an oral test and an evaluation of the experimental ability achieved by the student while attending to practical trainings in laboratory

Exam schedule