ENDOCRINE DISRUPTORS AND HUMAN HEALTH

ENDOCRINE DISRUPTORS AND HUMAN HEALTH

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iten
Code
61770
ACADEMIC YEAR
2019/2020
CREDITS
2 credits during the 2nd year of 9015 Molecular and health biology (LM-6) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR
BIO/09
LANGUAGE
Italian
TEACHING LOCATION
GENOVA (Molecular and health biology)
semester
1° Semester
Teaching materials

OVERVIEW

The course aims to provide students with an adequate study of the substances present in the environment and how they can interfere with the proper functioning of natural hormones in humans.

AIMS AND CONTENT

LEARNING OUTCOMES

The course aims to provide students with an adequate study of the substances present in the environment and how they can interfere with the proper functioning of natural hormones in humans.

AIMS AND LEARNING OUTCOMES

Participation in the planned training activities (lectures) will allow students of the MOLECULAR AND HEALTH BIOLOGY Course to acquire the general knowledge and fundamental notions about endocrine disrupters and the effects they may have on human health.

The course aims to define the endocrine disruptors (EDs), the modalities of dispersion and accumulation in the environment, the modalities of exposure, the adverse effects on human health, the molecular mechanisms with which they act and the legislation on the matter.

The student must be able to:

• Knowing the various calories of endocrine disruptors;

• Acquiring the mechanisms of interference with the endocrine system;

• Understanding the causality between exposure to a given ED and the onset of hormone dysmetabolism.

Skills acquired at the end of the course: At the end of the course the student must have acquired a general overview of the mechanisms of interference of all phases of synthesis of secretion, transport, action and degradation of lipophilic hormones both from a molecular and an organ point of view. The skills acquired will make it possible for the student to have an adequate understanding of international publications on endocrine disruptors.

PREREQUISITES

Knowledge of the Human Physiology program.

Knowledge of the main aspects of Endocrinology and Molecular Biology.

Teaching methods

The teaching consists of lectures. Attendance at lessons is strongly recommended. Part of the course could be carried out with didactic modalities different from lectures, eg: Problem based learning.

 

SYLLABUS/CONTENT

• Endocrine disrupters (EDs): definition and historical outline. Bioaccumulation, biomagnifications. NOAEL and LOEL. Molecular mechanisms of action of EDs. Assays for the identification of EDs.

• EDs and ovarian function: polycystic ovary syndrome, endometriosis. Leiomyoma / fibroma, precocious puberty, lowering of the probability of fertilization and pregnancy, preterm birth, underweight birth, alteration of the menstrual cycle.

• EDs and male reproductive health: congenital cryptorchidism, hypospadias, semen quality, testicular dysgenesis syndrome, germ cell carcinoma of the testis.

• EDs and thyroid hormones: goiter or thyroid nodules, congenital hypothyroidism, autoimmune thyroiditis, hyperthyroidism or Graves' disease, thyroid cancer.

• EDs and cancer: hormonal tumors of the breast, of the endometrium, of the ovaries, of the testicles, of the prostate and of the thyroid.

• EDs and alterations of lipid homeostasis.

RECOMMENDED READING/BIBLIOGRAPHY

Slides and material provided by the teacher

TEACHERS AND EXAM BOARD

Ricevimento: On appointment

Exam Board

ELENA GRASSELLI (President)

ILARIA DEMORI

LAURA CANESI

LESSONS

Teaching methods

The teaching consists of lectures. Attendance at lessons is strongly recommended. Part of the course could be carried out with didactic modalities different from lectures, eg: Problem based learning.

 

LESSONS START

To agree with the students

EXAMS

Exam description

During the course, each student is asked to participate in the Journal Club, which consists of summarizing and presenting a review or a paper published in scientific international journals through a brief exposure with power point. This activity will affect on the exam grade.

The examination procedure for the assessment of the achievement by the student of the objectives set will take place with an oral examination, and will always be conducted by a Commission consisting of at least two tenured teachers (or in cases limited by a tenured professor and an expert on the subject designated by the CCS). The Commission, appointed in this way, is able to verify with high accuracy the achievement of the educational objectives of the teaching.

Booking: https://servizionline.unige.it/studenti/esami/prenotazione

At least 3 calls will be available in the winter session (January-February) and 3 calls in the summer session (June, July, September).

Assessment methods

The Commission accurately verifies the achievement of the educational objectives of the teaching by asking different questions related to the program actually carried out during the lessons of the course. For the final evaluation of the student the commission will evaluate the following requirements: level of knowledge of the topics covered by the questions, exposure skills, ability to reason and link with other topics of the course. In the event that the training objectives are not achieved, the student is invited to better verify his / her knowledge and possibly to make use of further explanations by contacting the teacher in charge of the course.

Exam schedule

Date Time Location Type Notes
10/06/2020 09:00 GENOVA Orale
02/07/2020 09:00 GENOVA Orale
14/07/2020 09:00 GENOVA Orale
08/09/2020 09:00 GENOVA Orale