MOLECULAR AND CELLULAR PATHOLOGY

MOLECULAR AND CELLULAR PATHOLOGY

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iten
Code
66685
ACADEMIC YEAR
2019/2020
CREDITS
6 credits during the 2nd year of 9015 Molecular and health biology (LM-6) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR
MED/04
LANGUAGE
English
TEACHING LOCATION
GENOVA (Molecular and health biology)
semester
2° Semester
Prerequisites
Teaching materials

OVERVIEW

Cellular and Molecular Pathology  (6 CFU) is a mandatory exam in the 2nd year of the MHB course (sping period)

AIMS AND CONTENT

LEARNING OUTCOMES

This course aims at providing deep knowledge of the molecular mechanisms underlying the most important human diseases. The alterations of structures, functions and control mechanisms in degenerative pathologies as well as in neoplastic transformations will be studied at molecular, cellular and tissue level. Students will be able to use and apply this knowledge both in research activity and in clinical laboratory

AIMS AND LEARNING OUTCOMES

The deep knowledge of molecular mechanisms underlying the loss of homeostatic ability in tissues and the pathogenesis of the main human diseases is fundamental for the students and  will be crucial in student's research activity and in clinical laboratory activity as well. Specifically, the student will be able to 

- discriminate between the alterations of cells and tissues found in the main human pathologies and identify the molecular alterations that characterize them,

- describe molecular or cellular alterations common to different pathologies, 

- classify the different nosological entities, 

- acquire specific and specialized terminology

 

PREREQUISITES

The students are assumed to know the topics covered by the courses of biochemistry, human anatomy and physiology is fundamental to approach the course, in particular an in-depth knowledge of signal transduction, protein synthesis, mitochondrial functions, cell cycle, heart and blood vessels, lymphatic system, liver, pancreas, blood glucose control, blood functions, hemostatic control.

Teaching methods

The course consists of lectures delivered through multimedia presentations.

SYLLABUS/CONTENT

Cell adaptations: modifications of cell growth and differentiation. Atrophy, hypoplasia, hypertrophy, metaplasia.

Cell injury:  hypoxic/ischemic damage, chemical damage, free radical damage.

Cellular responses to stress: alteration of lysosoms, mitochondria, endoplasmic reticulum, cytoskeleton.

Cell death: necrosis/apoptosis

Cell and tissue degenerations: primary dysfunctions/intracellular accumulations/extracellular accumulations/pathological pigmentations.

Liver pathologies: Steatosis, Fibrosis, Cirrhosis

Hemosiderosis, Wilson Disease.

Amyloidosis

Atherosclerosis: pathogenesis and sequelae

Hemostasis and thrombosis

Bleeding diathesis: congenital and acquider disorders. CID

Vascular pathologies: edema, embolism, thrombosis, infarction, shock

Anemias (congenital and acquired), leucopoenia, leukocytosis, leukaemia

Diabetes: pathogenesis and sequelae

Nervous system pathologies: epilepsy, multiple sclerosis, tetanus (overview)

Parkinson Disease  and Alzheimer Disease: histological features and pathogenetic mechanisms

Neoplasia:

Tumor atypias. Metastasis

Benign tumors and cancers. histological classification. TNM system

Molecular mechanisms of carcinogenesis. Oncogenes and tumor suppressor genes

Carcinogenic compounds, radiations, biological agents

Immune system and cancer (overview)

Angiogenesis and cancer (overview)

RECOMMENDED READING/BIBLIOGRAPHY

All the slides used during the lectures and other teaching material will be available on AulaWeb at the end of each cycle of lessons together with other selected papers in pdf format.

The suggested books are available together with other books for further study at the teacher office.

Recommended texts for any further information:

Robbins e Cotran: Le basi patologiche delle malattie (ELSEVIER)

Rubin: Patologia (Casa Ed. Ambrosiana)

M. Pontieri: Patologia generale/ Fisiopatologia Generale – PICCIN

 

TEACHERS AND EXAM BOARD

Ricevimento: Anytime by appointment 

Exam Board

ANNA MARIA BASSI (President)

CARLO PENCO

MARIAPAOLA NITTI

LESSONS

Teaching methods

The course consists of lectures delivered through multimedia presentations.

LESSONS START

For lessons start and timetable go to the following link For lessons start and timetable go to the following link https://easyacademy.unige.it/portalestudenti/

EXAMS

Exam description

The oral examination consists of the answer to questions asked by the teacher on topics covered during the course.

 

Assessment methods

Three questions will be asked on the topics covered during the Course. To get a passing-grade for each question is mandatory to pass the exam. The final evaluation will take into account student ability to analyse in depht the topics, to use the specialistic vocabulary and to logically connect  different aspects of molecular pathology.

Exam schedule

Date Time Location Type Notes
19/06/2020 10:00 GENOVA Orale
10/07/2020 10:00 GENOVA Orale
24/07/2020 10:00 GENOVA Orale
04/09/2020 10:00 GENOVA Orale
18/09/2020 10:00 GENOVA Orale

FURTHER INFORMATION

Regular attendance at lectures is strongly recommended.