ETIOLOGY AND PATHOGENESIS OF DISEASES

ETIOLOGY AND PATHOGENESIS OF DISEASES

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iten
Code
72088
ACADEMIC YEAR
2019/2020
CREDITS
17 credits during the 2nd year of 8745 MEDICINE AND SURGERY (LM-41) GENOVA
LANGUAGE
Italian
TEACHING LOCATION
GENOVA (MEDICINE AND SURGERY)
Prerequisites
Teaching materials

OVERVIEW

The integrated course of Etiology and Pathogenesis of Diseases is divided in five modules, extending over the two semesters: Applied Biology (General Genetics), Molecular Biology, Medical Genetics (Human Genetics), General Pathology, and Microbiology. 
This course aims to introduce the student to the knowledge about the etiology and the pathogenesis of the diseases in humans both at the cellular and at the molecular levels.

 

AIMS AND CONTENT

LEARNING OUTCOMES

The Integrated course aims to: deepen the basic knowledge of molecular biology; understand the principles of molecular diagnostics for Mendelian traits and diseases as well as the underlying mechanisms and consequences of gene mutations; deepen the general basis of inheritance; know the fundamental study methods of complex hereditary diseases; introduce the student to the knowledge of the etiology and pathogenetic mechanisms of diseases in humans and to analyze their main cellular and molecular aspects; deepen the pathogenic effects of metabolic alterations, toxic substances and ionizing radiations; study the biology of pathogenic microorganisms and their possible effects on host cells and tissues; analyze the various immunological mechanisms involved in the immune responses and the pathologies associated to an altered function of the immune system.

PREREQUISITES

In order to deal with the contents of the course, students should have a good knowledge in the fields of biochemistry, cellular biology, human anatomy, and histology. 

TEACHERS AND EXAM BOARD

Ricevimento: make an appointment by e-mail paola.ghiorzo@unige.it, or telephone  0103538949-0105557255. Address: DiMI; Viale Benedetto XV, 6. Secondo floor , room  206

Ricevimento: By appointment. Please contact the Lecturer by e-mail (william.bruno@unige.it).

Ricevimento: Students may ask for explanations whenever they deem it necessary. They may write an email to soniscarfi@unige.it or by phone: 010 35338227. Scarfì's office it's located in Via A. Pastore 3, first floor ( in front of Mente locale Bar, fire escape).

Ricevimento: By appointment by email: mariacristina.mingari@unige.it

Ricevimento: Students have the possibility to contact the teacher by e-mail (claudia.cantoni@unige.it) or by phone (010 56362845) and ask for an appointment.  Address 1: Laboratorio di Immunologia Clinica e Sperimentale, Padiglione 2, Istituto G. Gaslini, L. go G. Gaslini 5 Address 2: Sezione di Patologia Generale - DIMES, Via L. Alberti, 2

Ricevimento: By appointment by email: gabriella.pietra@unige.it

Ricevimento: By e-mail : chiara.vitale@unige.it By phone : 010-5558219

Ricevimento: Students can contact the teachers by mail (maidep@unige.it) for interviews The teacher's studio is located in the Pathology Section of Experimental Medicine Department (DIMES) , via  L.B. Alberti, 2 16132 Genova

Ricevimento: An appointment, fixed by  an electronic request at the address: anna-marchese@unige.it, is needed

Ricevimento: By appointment by email: eugenio.debbia@unige.it

Ricevimento: make an appointment by e-mail apuliti@unige.it, or telephone 010-56362802. Address: UOC Genetica Medica, Istituto Giannina Gaslini, via Gaslini 5 Genova

Exam Board

GABRIELLA PIETRA (President)

ALDAMARIA PULITI (President)

SONIA SCARFI' (President)

CHIARA VITALE (President)

WILLIAM BRUNO (President)

MARIA CRISTINA MINGARI (President)

PAOLA GHIORZO (President)

VINCENZO DI PILATO (President)

ANNA MARIA SCHITO

MARIA ADELAIDE PRONZATO

EUGENIO DEBBIA

ANNA MARCHESE

CLAUDIA CANTONI

EXAMS

Exam description

For the modules carried on in the first semester, the exam consists of a written test. The total amount of time allowed for the examination is 90 minutes.
General Genetics section: 30 multiple choice questions and one open question, all to be answered in 30 minutes. The exam includes the resolution of genetics problems and the exposure of molecular genetics topics.

Molecular Biology section: 20 multiple choice questions and one open question, all to be answered in 30 minutes.

Human Genetics section: 20 multiple choice questions (including 10 problems and 10 questions on theoretical knowledge), all to be answered in 30 minutes.

The examination for the integrated course is made up of a single written exam for the 3 sub-sections.  The chance to carry out a supplementary oral examination is available both to students whose final average mark is between 16 and 17/30 (14/30 at least for each module)  and  to those who wish to increase the mark (above 18/30) they obtained in the written examination

The final mark of the written exam derives from the average of marks obtained in the single sections.

Correction of the written tests and the supplementary oral examination require at least one week.

For the modules carried on in the second semester, the exam is an oral one. Students are allowed to undergo the oral examination only if they have passed the test concerning the modules of the first semester with at least 18/30 (this mark is valid for 18 months).

The oral examination consists of a 30 minutes interview in the presence of the course teachers. The student, in the presence of the committee, should demonstrate the ability to critically discuss all the subjects covered in the questions. Through the discussion of different topics, the committee verifies the fulfillment of the expected earning outcomes.

At the end of the oral examination, teachers elaborate a mark deriving from the weighted mean of the partial/preliminary marks and from an overall judgment/evaluation of the student.

The mark 30/30 with honors will be assigned when the knowledge of the subject is excellent.

Assessment methods

Verification of learning is carried out through the oral exam, aimed at verifying the real acquisition by the student of the expected learning outcomes.
In order to pass the exam the student will have to demonstrate a good knowledge of the etiological basis and the pathogenic mechanisms of diseases I humans and the ability to analyze their main cellular and molecular aspects;
The following items will contribute to the final mark:
- ability to critically discuss the requested topics;
- accuracy, clarity, synthesis and fluency;
- competence in the subject;
- speaking ability and correct use of terminology.

Exam schedule

Date Time Location Type Notes
11/06/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
17/06/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
02/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
08/07/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
21/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
22/07/2020 09:00 GENOVA Orale Sede: Aula 3 - Polo Alberti
11/09/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
21/09/2020 09:00 GENOVA Orale Sede: Aula di Patologia Generale - Via Alberti 2
11/06/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
17/06/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
02/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
08/07/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
21/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
22/07/2020 09:00 GENOVA Orale Sede: Aula 3 - Polo Alberti
11/09/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
21/09/2020 09:00 GENOVA Orale Sede: Aula di Patologia Generale - Via Alberti 2
11/06/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
17/06/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
02/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
08/07/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
21/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
22/07/2020 09:00 GENOVA Orale Sede: Aula 3 - Polo Alberti
11/09/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
21/09/2020 09:00 GENOVA Orale Sede: Aula di Patologia Generale - Via Alberti 2
11/06/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
17/06/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
02/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
08/07/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
21/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
22/07/2020 09:00 GENOVA Orale Sede: Aula 3 - Polo Alberti
11/09/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
21/09/2020 09:00 GENOVA Orale Sede: Aula di Patologia Generale - Via Alberti 2
11/06/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
17/06/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
02/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
08/07/2020 09:00 GENOVA Orale Sede: Aula 6 - Polo Alberti
21/07/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
22/07/2020 09:00 GENOVA Orale Sede: Aula 3 - Polo Alberti
11/09/2020 09:00 GENOVA Scritto 08/01/2020 Aule 1 e 34 Polo Biomedico 05/02/2020 Aule 1 e 2 Polo Biomedico 25/02/2020 Aule 1 e 2 Polo Biomedico 11/06/2020 Aula 1 Polo Biomedico 02/07/2020 Aula 1 Polo Biomedico 21/07/2020 Aula 8 Polo Biomedico 11/09/2020 Aula 8 Polo Biomedico ore 9.00
21/09/2020 09:00 GENOVA Orale Sede: Aula di Patologia Generale - Via Alberti 2