PROTEIN ENGINEERING

PROTEIN ENGINEERING

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Code
95322
ACADEMIC YEAR
2018/2019
CREDITS
5 credits during the 2nd year of 10598 MEDICAL-PHARMACEUTICAL BIOTECHNOLOGY (LM-9) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR
BIO/10
LANGUAGE
English
TEACHING LOCATION
GENOVA (MEDICAL-PHARMACEUTICAL BIOTECHNOLOGY)
semester
2° Semester
Teaching materials
More information regarding this unit may be available in Italian.

AIMS AND CONTENT

LEARNING OUTCOMES

The aim of the course is to provide students with theoretical knowledge but also practical on the assumptions and techniques underlying the engineering of proteins and antibodies. In addition, part of the course will be dedicated to the deepening of the techniques of chemical synthesis of proteins. Regarding the form of Protein engineering, will initially be resumed and expanded some concettivi base relative to the production of recombinant proteins. Thus, different approaches will be analyzed in order to obtain modified proteins or optimized for different applications, the techniques used and the systems of selection / screening, and using examples from the literature or used for production / commercial. In the section of the course on the engineering of antibodies will be given with the three-dimensional structure of immunoglobulins and will be addressed later, in the chronological order of creation, the different techniques of humanization and production of recombinant phage display antibody. In the form of Chemical Engineering explain the main techniques for the chemical synthesis of peptides and proteins and applications resulting from these techniques.

TEACHERS AND EXAM BOARD

Ricevimento: The teacher receives by appointment at Biochemistry - DIMES, Viale Benedetto XV No. 1, first floor, Genoa. The talks may take place, by appointment, also via Skype For appointments please send an email to: tonetti@unige.it.

Ricevimento: By appointment, email: fghiotto@unige.it

Ricevimento: By appointment by email: Enrico.Millo@unige.it

Exam Board

MICHELA TONETTI (President)

ENRICO MILLO (President)

FABIO GIUSEPPE GHIOTTO (President)