POLYMERIC BIOMATERIALS

POLYMERIC BIOMATERIALS

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iten
Code
64767
ACADEMIC YEAR
2018/2019
CREDITS
4 credits during the 1st year of 9020 Industrial Chemistry (LM-71) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR
CHIM/04
LANGUAGE
Italian
TEACHING LOCATION
GENOVA (Industrial Chemistry)
semester
2° Semester
Teaching materials

OVERVIEW

This course provides the fundamentals required to correlate the molecular, chemical-physical, mechanical and thermal properties of biomaterials with their functions in biological systems. The different classes of biomaterials, especially the polymeric-based ones, their application uses and the main technological approaches applied in biomedical and pharmacological fields are described.

AIMS AND CONTENT

LEARNING OUTCOMES

Knowledge of the main chemical, physical, mechanical properties of biomaterials, especially those of polymeric nature. Acquisition of basic notions about biofunctionality, biocompatibility and hemocompatibility and on issues related to the interactions of biomaterials with biological systems. Examples of specific applications and development strategies of biomaterials.

AIMS AND LEARNING OUTCOMES

The course aims to provide the basic principles underlying the biomedical engineering and the production of devices for controlled drug delivery in order to develop the student's ability to apply the theoretical knowledge to formulate general criteria for the design, synthesis, functionalization and characterization of innovative materials and systems. At the end of the course the student will be able to:

·         know the main classes of polymeric materials employed in biomedical field and properly define their application areas;

·         correlate the properties of polymeric materials with their use in biomedical and pharmacological domains;

·         correlate the properties of polymeric materials with their biocompatibility/hemocompatibility and suggest general criteria to improve and/or optimize the latter parameters;

·         individuate the most suitable characterization techniques of biomaterials according to their specific use;

-          evaluate the current processing technologies to produce biomedical and pharmacological devices according to their specific use.

PREREQUISITES

It may be useful to have followed a basic course on polymer and biochemistry.

Teaching methods

The teaching consists of traditional lectures for a total of 32 hours, sometimes accompanied with exercises carried out by the teacher in the classroom. Lesson notes are uploaded to the corresponding AulaWeb simultaneously with their content presentation in the classroom.

In order to facilitate the individual preparation, verification tests are uploaded to the corresponding AulaWeb page.

SYLLABUS/CONTENT

Classification of biomaterials.

Polymeric and composite biomaterials.

Biodegradable, bioresorbable and bioactive materials.

Interaction of biomaterials outside of the blood flow: biostability and biocompatibility.

Interaction of biomaterials within the blood flow: hemocompatibility and thrombogenicity.

Analysis of biomaterial surfaces: characterization techniques and treatment/functionalization protocols.

Polymeric biomaterials for orthopedic, dental, and ophthalmological devices.

Polymeric biomaterials for soft tissues.

Polymeric biomaterials for cardiovascular devices.

Regenerative medical science: tissue engineering and biomimetic materials.

Mono-, bi-, and tridimensional scaffolds for tissue architecture: materials and fabrication techniques.

Controlled drug delivery systems (DDS).

RECOMMENDED READING/BIBLIOGRAPHY

R. Pietrabissa, “Biomateriali per Protesi e Organi Artificiali”, Patron Ed. Bologna, 1996

R. Fumero, P. Giusti, “Biomateriali: dalla ricerca di base all’applicazione clinica”, Patron Ed., Bologna, 1985

C. Di Bello, “Biomateriali-Introduzione allo Studio”, Patron Ed., Bologna, 2005

A. Atala, “Principles of regenerative medicine”, 2nd edition, London: Academic, 2010

“Perspectives on biomaterials: proceedings on the 1985 International Symposium on Biomaterials”, O.C.C- Lin & E.Y.S. Chao, Eds., 1985 

J.B. Park, R.S. Lakes, “Biomaterials-An Introduction”, Springer-Verlag, N.Y. Inc., 2007

A.F. von Recum, “Handbook of Biomaterials Evaluation: Scientific, Technical and Clinical Testing of Implant Materials”, CRC Press, 1999 (ISBN 1560324791)

TEACHERS AND EXAM BOARD

Ricevimento: Every day by appointment.

Exam Board

MARINA ALLOISIO (President)

SILVIA VICINI

MASSIMO OTTONELLI

CAMILLA COSTA

MAILA CASTELLANO

LESSONS

Teaching methods

The teaching consists of traditional lectures for a total of 32 hours, sometimes accompanied with exercises carried out by the teacher in the classroom. Lesson notes are uploaded to the corresponding AulaWeb simultaneously with their content presentation in the classroom.

In order to facilitate the individual preparation, verification tests are uploaded to the corresponding AulaWeb page.

LESSONS START

Available on the official website of Industrial Chemistry degree as soon as the timetable is defined.

ORARI

L'orario di tutti gli insegnamenti è consultabile su EasyAcademy.

EXAMS

Exam description

The exam is an oral examination conducted by two teachers for a duration of at least 30 minutes. During the calendar year, seven exam dates are set up within the time intervals scheduled by the Manifesto degli Studi.

The oral examination consists of two parts; both of them are awarded a maximum rating of 15/30 for the exam evaluation:

- in the first part the student has to face a problem with the use of polymeric materials in the biomedical field in order to verify his comprehension and mastery of the course topics as well as his ability to apply theoretical concepts to real situations. Alternatively, and only by the student's choice, the first part of the exam can cover a topic, chosen by the student himself and approved by the teacher, which is related to the course but not included in the program. In the latter case, the exam is subordinated to the delivery of a report on the subject, according to the terms fixed by the teacher.

- in the second part, the student is called upon to answer two questions related to topics of the course program, chosen by the exam committee. 

Assessment methods

Goal of the assessment is to verify the student's ability to correlate the potentialities of the various biomaterials with their chemical, physical mechanical and thermal properties. If the learning outcomes are not achieved, the student is invited to deepen his preparation also by taking advantage of further explanations by the teacher before repeating the exam. The student’s ability to compare and integrate the data available from different characterization and processing techniques included in the course program will also be evaluated, together with the student’s language skills.

As a quality assurance, the detailed program of the course is uploaded to the corresponding AulaWeb page, so that students can verify the correspondence between topics and learning outcomes.

FURTHER INFORMATION

No official pre-requisites required. However, it may be useful to have followed a basic course on polymer and biochemistry.