DRUG SYNTHESIS (WITH PRACTICE)

DRUG SYNTHESIS (WITH PRACTICE)

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Code
80453
ACADEMIC YEAR
2018/2019
CREDITS
5 credits during the 5th year of 8451 Pharmaceutical chemistry and technology (LM-13) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR
CHIM/08
LANGUAGE
Italian
TEACHING LOCATION
GENOVA (Pharmaceutical chemistry and technology)
semester
1° Semester
Teaching materials

OVERVIEW

The "DRUGS SYNTHESIS" Teaching program is aimed at students of the fifth year of the Cycle Degree Program in Pharmaceutical Chemistry and Technology (CTF). Teaching allows you to acquire 5 CFUs and consists of a theoretical part and a practice of individual exercises in the synthesis lab.

AIMS AND CONTENT

LEARNING OUTCOMES

 

The course aims to introduce the student to the synthesis techniques applied to the preparation of drugs.

AIMS AND LEARNING OUTCOMES

In particular, the student must acquire the ability to plan and implement the preparation of certain drugs by applying classic or innovative synthetic pathways (step-by-step, one pot, parallel synthesis, etc.). To apply the main isolation and purification methods of finished products from reaction mixtures, to characterize finished products through common analytical techniques. In addition, the theoretical notions concerning the synthetic methods applied, as well as the necessary and complementary activities of the synthesis (isolation, extraction, purification, anhydration, drying, etc.) will be required.

Teaching methods

The lecturer will hold the frontal lectures in the classroom with the help of slides that will be made available to students for study at the end of the course.
Exercises will be introduced by a brief lesson that will be held in the classroom or in the same workshop.
The exercises will be individual but to rationalize the use of the available space the students will be divided into working pairs.
For the sake of space and for maximum security, the experiments will be carried out by no more than 10-11 pairs at the same time, so they will be carried out on different shifts in relation to the number of students.

SYLLABUS/CONTENT

The course consists of theoretical lessons and practical exercises. The 5 CFUs (60 hours of frontal / student learning engagement) will be divided into 20 hours of classroom lesson and 40 hours of laboratory exercise.
Theoretical lessons: Safety standards in the synthesis lab. The synthesis lab notebook. How to synthesize a drug. Reagents and solvents: choice, storage, use, disposal; The anhydrous solvents. Catalysts. Classic synthesis: the glassware and the main equipment used. Parallel synthesis and combinatorial synthesis: theoretical ideas and equipment. Microwave-assisted reactions: theoretical ideas and equipment. The reactions in the absence of solvent, theoretical considerations. Flow reactions, theoretical outlines and equipment. The purification techniques of reaction mixtures (solvent extraction, chromatographic separation, crystallization, distillation). The characterization of a "finished" compound: the analytical techniques used to determine structure and purity.
Exercises
Starting from the known drug structure, the student will be guided to plan a synthetic strategy based on the knowledge acquired in the courses of organic chemistry and pharmaceutical chemistry. In addition, the student will be able to conduct online research on specialized databases to verify the existence of known procedures in the literature that can be applied to the lab. The designed synthesis will be carried out in the laboratory and the products obtained will be purified and characterized.

RECOMMENDED READING/BIBLIOGRAPHY

There are no textbooks covering all the topics in a single volume and therefore the teacher prefers not to give specific indications and instead provide the tools needed by the students to find the necessary information to prepare the exam.

The documentation required for experiments will be provided through Aulaweb or in the laboratory. Any bibliographic information relating to the applied synthesis will be obtained through special research on dedicated databases (SCIFINDER, Reaxis) and by the school library system.

TEACHERS AND EXAM BOARD

Ricevimento: Friday morning (10-11 am)

Exam Board

OLGA BRUNO (President)

MICHELE TONELLI

ANDREA SPALLAROSSA

LESSONS

Teaching methods

The lecturer will hold the frontal lectures in the classroom with the help of slides that will be made available to students for study at the end of the course.
Exercises will be introduced by a brief lesson that will be held in the classroom or in the same workshop.
The exercises will be individual but to rationalize the use of the available space the students will be divided into working pairs.
For the sake of space and for maximum security, the experiments will be carried out by no more than 10-11 pairs at the same time, so they will be carried out on different shifts in relation to the number of students.

EXAMS

Exam description

Each exercise involves drafting a report that will be delivered at the beginning of the next tutorial. At the end, a global vote will be assigned to experimental work.
The exam will be oral, conducted on questions related to theoretical lessons and practical experiments. The final vote will be an average of the vote of the interview and of the practical exercises.

Assessment methods

Written report for each exercise. Oral examination.